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Substituted diketopiperazines and salts thereof for drug delivery agents, therapeutic compositions containing them, fine particle compositions and dry powder compositions, and methods for preparing the same
专利权人:
マンカインド コーポレイション
发明人:
クラフト,ケリー・サリバン,クラフト,ケリー・サリバン
申请号:
JP2011543723
公开号:
JP5788806B2
申请日:
2009.12.29
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
The present invention provides an asymmetrically substituted diketopiperazine having the general structure of: wherein R is H or an alkyl group of 1-10 carbons; n or m = 0 -20; X is an amide, ester, sulfone, sulfoxide, amine, or ketone; and Y is an amide, ester, acid, hydroxyl, phenol, sulfoxide, phosphoric acid, or thiol, for use as a drug delivery system in the delivery of active agents. Further preferred uses include regulating blood glucose levels, reducing or lowering fasting blood glucose levels, and treating diabetes, such as type II diabetes.
来源网站:
中国工程科技知识中心
来源网址:
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