CHINESE ACADEMY OF SCIENCES;FUJIAN INSTITUTE OF RESEARCH ON THE STRUCTURE OF MATTER
发明人:
LU, CANZHONG,YONG, JIANPING
申请号：
EP12872724
公开号：
EP2752413A4
申请日:
2012.03.26
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
This invention provides a class of quinazoline compounds, as represented by formula (I), and their pharmaceutically acceptable salts, wherein: each of R 1 and R 2 independently, is selected from H, C 1 -C 6 alkoxy, halo-C 1 -C 6 alkoxy, C 1 -C 6 -alkoxy-C 1 -C 6 alkoxy, C 3 -C 8 cycloalkoxy, C 3 -C 8 heterocycloalkoxy containing at least one of heteroatoms selected from N, O, S； Z is -NR 4 -, C(R 5 ) 2 , S or -O-, wherein R 4 is H or C 1 -C 3 alkyl, R 5 is the same or different, selected from H or C 1 -C 3 alkyl； R 3 is selected from H, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy or halo-C 1 -C 6 alkyl； n is an integer from 0 to 5. This invention also provides methods of preparation and medical uses of the compounds of formula (I) and their pharmaceutically acceptable salts. These compounds have the activity of inhibiting EGFR-TK, and can be used as drugs for the treatment of protein tyrosine kinase related diseases such as tumours, cancers, etc.
