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AN IMPROVED PROCESS FOR THE PREPARATION OF DEFERASIROX AND ITS SALT
专利权人:
发明人:
GHARPURE MILIND,PATIL SACHIN,TARATE PRAKASH,KADAM SANTOSH,KUMBHAR AJAY,SHELKAR PRAVIN,TODEWALE ISMAIL
申请号:
IN201621044970
公开号:
IN201621044970A
申请日:
2016.12.30
申请国别(地区):
IN
年份:
2018
代理人:
摘要:
The present invention provides an improved process for the preparation of pure 4-(3,5-bis(2-hydroxyphenyl)-lH-l,2,4-triazol-l- yl)benzoic acid (I) commonly known as Deferasirox or its salt containing hydrazine impurity less than about 0.75 ppm comprising treating the crude deferasirox with oxone. In addition, the present invention provides an improved process for the preparation of pure 4-(3,5-bis(2-hydroxyphenyl)-lH-l,2,4-triazol-l-yl)benzoic acid (I) commonly known as Deferasirox or its salt containing hydrazine impurity less than about 0.75 ppm comprising treating the crude deferasirox with a ketone solvent.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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