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PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRIMIDINE DERIVATIVES
专利权人:
JANSSEN PHARMACEUTICA N.V.
发明人:
CESCO-CANCIAN, SERGIO,CHEN, HONGFENG,GRIMM, JEFFREY, S,MANI, NEELAKANDHA, S,MAPES, CHRISTOPHER, M,PALMER, DAVID, C,PIPPEL, DANIEL, J,SORGI, KIRK, L,XIAO, TONG
申请号:
NZ59017009
公开号:
NZ590170A
申请日:
2009.06.29
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed herein is a process for the preparation of a compound of formula (I), in particular a compound of formula (I-S), wherein the substituents are as defined within the specification, wherein the process comprises reacting a compound of formula (V) with a compound of formula (VI) in a first organic solvent and in the presence of a coupling agent system to yield the corresponding compound of formula (VII), de-protecting the compound of formula (VII), to yield the corresponding compound of formula (VIII) and followed by reacting the compound of formula (VIII) with a compound of formula (IX) in a second organic solvent to yield the corresponding compound of formula (I).
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