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Delamanide and its pharmaceutically acceptable derivatives
专利权人:
OTSUKA PHARMACEUTICAL CO LTD
发明人:
申请号:
LU92517
公开号:
LU92517I2
申请日:
2014.08.13
申请国别(地区):
LU
年份:
2014
代理人:
摘要:
The present invention provides a 2,3-dihydro-6-nitroimidazoÄ2,1-bÜoxazole compound represented by the following general formula: <;CHEM>; wherein R<;1>; represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R<;2>; represents a group -OR<;3>; or the like, and R<;3>; represents a hydrogen atom, C1-C6 alkyl group or the like, or R<;1>; and -(CH2)nR<;2>; may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H): <;CHEM>; wherein R<;41>; is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and a typical acid-fast bacteria.
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