The present invention provides a method for improving pancreatic function in asubject in need thereof, themethod comprising administering to the subject STRO-1+ cells and / or progenycells thereof and / or soluble factors derived therefrom.The method of the invention is useful for treating and / or preventing and /or delaying the onset or progression of a disorderresulting from or associated with pancreatic dysfunction, e.g., resulting fromabnormal endocrine or exocrine function of the pancreas.
