СПОСОБ ПОЛУЧЕНИЯ (±)N-[1-(4-ФТОРФЕНИЛ)-2-(1-ЭТИЛПИПЕРИДИН-4-ИЛ)ЭТИЛ]-4-НИТРОБЕНЗАМИДА ИЛИ ЕГО ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫХ СОЛЕЙ И ПРОМЕЖУТОЧНОЕ СОЕДИНЕНИЕ ДЛЯ ЕГО ПОЛУЧЕНИЯ
1. A process for preparing (±) N- [1- (4-fluorophenyl) -2- (1-ethylpiperidine-4-yl) ethyl] -4-nitrobenzamide of formula or pharmaceutically acceptable salts, consisting in that ethyl 4- fluorobenzoic acid is reacted with 4-picoline in tetrahydrofuran in the presence of a catalyst or a condensing agent to give 1- (4-fluorophenyl) -2- (4-pyridyl) ethanone, which is alkylated etilgalogenidom and the resulting pyridinium salt is subjected to catalytic reduction with hydrogen in the presence of a palladium or a platinum catalyst with addition of ontsentrirovannoy hydrochloric acid to obtain 2- (1-ethylpiperidine-4-yl) -1- (4-fluorophenyl) ethanone formulykotory subjected to reductive amination to give [2- (1-ethylpiperidine-4-yl) -1- (4- fluorophenyl) ethyl] amine, followed by reaction of the latter with an acid chloride of 4-nitrobenzoic acid to give (±) N- [1- (4-fluorophenyl) -2- (1-ethylpiperidine-4-yl) ethyl] -4-nitrobenzamide of formula (I) in free form or in a pharmaceutically acceptable soli.2. A method according to claim 1, characterized in that the hydrochloride of (±) N- [1- (4-fluorophenyl) -2- (1-ethylpiperidine-4-yl) ethyl] -4-nitrobenzamide of Formula (I) .3. A method according to claim 1, characterized in that the condensing agent is sodium bis (trimethylsilyl) amide in an amount of 1-2 mol per mol of 4-ftorbenzoata.4. 2- (1-ethylpiperidine-4-yl) -1- (4-fluorophenyl) ethanone, corresponding to formula (II) 5. Use of 2- (1-ethylpiperidine-4-yl) -1- (4-fluorophenyl) ethanone, corresponding to formula (II) as an intermediate for the synthesis of (±) N-1 [- (4-fluorophenyl) -2- ( 1-ethyl-4-piperidyl) ethyl] -4-nitrobenzamide in free form or in the form of pharmaceutically acceptable salts.1. Способ получения (±)N-[1-(4-фторфенил)-2-(1-этилпиперидин-4-ил)этил]-4-нитробензамида формулыили его фармацевтически приемлемых солей, заключающийся в том, что этиловый эфир 4-фторбензойной кислоты подвергают реакции с 4-пиколином в тетрагидрофуране в присутствии катализа
