Device (100) for cold plasma endoscopy comprising:- a cold plasma generating system (10) comprising:∘ a gas source (11),∘ an electrical source (12),∘ a cold plasma chamber (13) comprising:▪ a dielectric chamber (14) fluidly connected to said gas source (11),▪ a first electrode (15) surrounding at least partially said dielectric chamber (14) and electrically connected to said electrical energy source (12);- a first flexible tube (20) having a first lumen (25) fluidly connected to said dielectric chamber (14);said device (100) further comprising:- electrically conductive means (27) positioned at least partially inside said first lumen (25).