Refers to compounds 5 - fluoro substituted 1h pirazolopiridinas of formula (i) wherein R1 is H or alkyl (c1-c4) optionally substituted with Fluorine or trifluoromethyl.Preferred compounds are ethane-1,2-disulfonate {4, 4 - diamino - 2 - 5 - fluoro - [1 - (2-fluorobenzyl) - 1H pyrazolo [3,4-b] pyridin-3-yl] pyrimidin-5-yl} {maleate, Methyl carbamate, 4,6-diamino-2 - 5 - fluoro - [1 - (2-fluorobenzyl) - 1H pyrazolo [3,4-b] pyridin-3-yl] methylcarbamate among others. It also refers to a procedure of Preparation and to a Pharmaceutical composition.These compounds are soluble guanylate cyclase STIMULATORS of being useful for the treatment of angina pectoris, ischemia, heart failure.SE REFIERE A COMPUESTOS 5-FLUORO-1H-PIRAZOLOPIRIDINAS SUSTITUIDAS DE FORMULA (I) DONDE R1 ES H O ALQUILO (C1-C4) OPCIONALMENTE SUSTITUIDO CON FLUOR O TRIFLUOROMETILO. SON COMPUESTOS PREFERIDOS ETANO-1,2-DISULFONATO DE {4, 6-DIAMINO-2-[5-FLUORO-1-(2-FLUOROBENCIL)-1H-PIRAZOLO[3,4-b]PIRIDIN-3-IL]PIRIMIDIN-5-IL}CARBAMATO DE METILO, MALEATO DE {4,6-DIAMINO-2-[5-FLUORO-1-(2-FLUOROBENCIL)-1H-PIRAZOLO[3,4-b]PIRIDIN-3-IL]CARBAMATO DE METILO ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMINETO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ESTIMULADORES DE LA GUANILATOCICLASA SOLUBLE SIENDO UTILES PARA EL TRATAMIENTO DE ANGINA PECTORIS, ISQUEMIAS, INSUFICIENCIA CARDIACA.
