Ronald T. Raines,Thomas J. Rutkoski,John A. Kink,Laura E. Strong
申请号：
US12247438
公开号：
US08697062B2
申请日:
2008.10.08
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates generally to conjugates of human ribonucleases and water-soluble polymers, compositions comprising the conjugates and methods of using the same. In particular, the present invention provides conjugates of human ribonucleases and one or more water-soluble polymer compositions (e.g., to increase serum half-life and a pharmacokinetic profile, in vivo biological activity, stability, and/or reduce host immune response to the protein in vivo) as well as methods of using the conjugates in the therapy, treatment, and/or prevention of disease (e.g., cancer).
