METHOD FOR THE PRODUCTION OF A SOLID, ORALLY APPLICABLE PHARMACEUTICAL COMPOSITION COMPRISING 5-Chlor-N ( š (5-2-oxo-3- Š4- (3-oxo-4-morpholinyl)-phenylĆ-1, 3- oxazolidin-5-ylć-methyl)-2-thiophencarboxamide
Production of solid, orally administered pharmaceutical compositions (A) containing 5-chloro-N-(((5S)-2-oxo-3-(4-(3-oxo-4-morpholinyl)-phenyl)-1,3-oxazolidin-5-yl)-methyl)-2-thiophene-carboxamide (I) in hydrophilized form comprises: (a) preparing granules containing (I) in hydrophilized form by wet granulation and (b) converting the granules, optionally with suitable additives, into (A). Independent claims are included for: (1) the compositions (A) obtained by the process and (2) solid, orally administered pharmaceutical compositions (A) containing (I) in hydrophilized form in general. ACTIVITY : Thrombolytic Anticoagulant Cardiant Antianginal Vasotropic Cerebroprotective. MECHANISM OF ACTION : Coagulation factor Xa inhibitor.
