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DÉRIVÉS DE LA DOLASTATINE 10 ET AURISTATINES
专利权人:
PIERRE FABRE MEDICAMENT
发明人:
申请号:
EP18172389.1
公开号:
EP3388427A1
申请日:
2014.04.25
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention concerns a compound of following formula (I):where:- R1 is H or OH,- R2 is a (C1-C6)alkyl, COOH, COO-((C1-C6)alkyl) or thiazolyl group,- R3 is H or a (C1-C6)alkyl group, and- R4 is:▪ a straight-chain or branched, saturated or unsaturated hydrocarbon group having 1 to 8 carbon atoms substituted by one or more groups chosen from among OH and NR5R6,▪ -(CH2CH2X1)(CH2CH2X2)a2(CH2CH2X3)a3(CH2CH2X4)a4(CH2CH2X5)a5P7,▪ an aryl-(C1-C8)alkyl group substituted by one or more groups chosen from among OH and NR9R10 groups, or▪ a heterocycle-(C1-C8)alkyl group optionally substituted by one or more groups chosen from among (C1-C6)alkyl, OH and NR12R13 groups,or a pharmaceutically acceptable salt, hydrate or solvate thereof,and its uses in particular for the treatment of cancer, pharmaceutical compositions containing the same and the preparation methods thereof.
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