BHASKAR VINAY,CORBIN JOHN,WHITE MARK LESLIE,WATSON SUSAN R.
申请号：
NZ62536010
公开号：
NZ625360A
申请日:
2010.09.25
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is an allosteric agonist antibody that binds to insulin receptor with an affinity of 10-5,10-6, 10-7, 10-8, 10-9, 10-10, 10-11 M or less and (a) exhibits maximal agonist activity in the absence of insulin that is 20%-80% that of insulin&rsquo；s maximal agonist activity when measured in pAKT assay, (b) when present with insulin does not alter the EC50 of insulin for INSR by more than 2-fold, and (c) when present with insulin does not alter the KD of insulin for INSR by more than 2-fold.
