A non-naturally occurring compound that specifically binds to a T1R2/T1R3 receptor composed of hT1R2/hT1R3, having a potency as a modulator of the T1R2/T1R3 receptor as determined by an EC50 of less than about 1 mM or by an EC50 ratio of at least 1.20, wherein the non-naturally occurring compound is an amide compound.