The present invention provides a hollow fiber membrane-type blood purification device in which a hollow fiber membrane is packed into a receptacle, wherein the hollow fiber membrane includes a hydrophobic polymer, a hydrophilic polymer, and a fat-soluble material, the amount of the fat-soluble material on the inner surface of the hollow fiber membrane is 10mg/m2 to 300mg/m2, and the oxygen permeation coefficient of the receptacle is no more than 1.8*10-10cm3-cm/(cm2-s-cmHg).本發明提供一種中空絲膜型血液淨化裝置，其係於容器中填充有中空絲膜者，並且該中空絲膜包含疏水性高分子、親水性高分子及脂溶性物質，該中空絲膜之內表面之脂溶性物質量為10mg/m2以上且300mg/m2以下，且該容器之透氧係數為1.8×10-10cm3‧cm/(cm2‧s‧cmHg)以下。
