The present invention provides a hollow-fiber membrane blood purification device obtained by filling a container with a hollow-fiber membrane, in which the hollow-fiber membrane contains a hydrophobic polymer, a hydrophilic polymer and a lipid-soluble substance the amount of the lipid-soluble substance on the inner surface of the hollow-fiber membrane is 10 mg/m 2 or more and 300 mg/m 2 or less and the oxygen transmission rate of the container is 1.8 × 10 -10 cm 3 ·cm/(cm 2 ·s·cmHg) or less.
