The invention refers to a handheld injection device comprising a housing (10 210 410), a piston rod (30 230 530), defining a first longitudinal axis (I) and located within the housing (10 210 410), a driver (40 241, 242 500) coupled to the piston rod (30 230 530), a dose setting means (60, 70), which is rotatable about a second longitudinal axis (II) during dose setting, and optionally a power reservoir (90 290 10) for driving the driver (40 241, 242 500) and/or a release clutch (15, 45 300 06) preventing rotation of the driver (40 241, 242 500) during dose setting and allowing rotation of the driver (40 241, 242 500) during dose dispensing. The first longitudinal axis (I) is spaced from the second longitudinal axis (II).
