As with what treatment diabetes SGLT2 inhibitor (1S) -1,The recrystallisation solvent of 5- dehydrations-L-C- (3- ((phenyl) methyl) phenyl)-D-Glucose 01 derivatives and amino acid closes object and complex compound农业专利-农业学术服务平台

发明人:: J.Z.古古塔斯,H.罗宾格,H.羅賓格,S.拉马克里什南,S.拉馬克里什南,P.P.德什潘德,J.T.比恩,赖佳仁,賴佳仁,王贞棋,王貞棋,P.里贝尔,P.里貝爾,J.A.格罗索,J.A.格羅索,A.A.尼尔希尔,A.A.尼爾希爾,J.辛格,J.D.迪马科,J.D.迪馬科

摘要：: The present invention relates to as with what treatment diabetes SGLT2 inhibitor (1S) -1,The recrystallisation solvent of 5- dehydrations-L-C- (3- ((phenyl) methyl) phenyl)-D-Glucose 01 derivatives and amino acid closes object and complex compound, specifically, the physical crystalline structure of the compound of Formulas I: wherein R1, R2, R2a, R3 and R4 are defined as in the description, the pharmaceutical composition of structure especially containing compound I or II, their preparation method, intermediate used in its preparation, and the method using this kind of structure treatment disease such as diabetes.本發明涉及作爲用於治療糖尿病的SGLT2抑制劑的(1S)-1,5-脫水-L-C-(3-((苯基)甲基)苯基)-D-葡萄糖醇衍生物與氨基酸的結晶溶劑合物和絡合物，具體地，式I的化合物的物理晶體結構：其中R1、R2、R2a、R3和R4如說明書所定義，尤其是含有化合物I或II的結構的藥物組合物，它們的製備方法，其製備中所用的中間體，和使用這類結構治療疾病如糖尿病的方法。