The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising a monoclonal antibody, partial antibody. Fab Fragment, antibody fragment that is tagged with a fluorophore with or without the addition of a therapeutic chemotherapy molecule, which specifically binds to the targeted organ, tissue or cell. Resection of the primary malignant tissue within the mammalian species provides the advantage of identifying all bulk tumor as fluorescent at the time of the original tumor resection. Additional therapy is provided by the chemotherapy molecule that is bound to the fluorescent-tagged monoclonal antibody.
