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METHOD FOR COMBINED IMAGING AND TREATING ORGANS AND TISSUES
专利权人:
ONCOFLUOR; INC.
发明人:
LUIKEN, GEORGE, A.
申请号:
EP12738941
公开号:
EP2667766A4
申请日:
2012.01.25
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising a monoclonal antibody (chimeric, humanized, fully human), partial antibody, Fab Fragment, antibody fragment that is tagged with a fluorophore with or without the addition of a therapeutic chemotherapy molecule, which specifically binds to the targeted organ, tissue or cell. Resection of the primary malignant tissue within the mammalian species (using the fluorescence of the fluorescing targeting construct) provides the advantage of identifying all bulk tumor as fluorescent at the time of the original tumor resection.
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