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NOVEL CHROMENONE POTASSIUM CHANNEL BLOCKERS AND USES THEREOF
专利权人:
BIONOMICS LIMITED
发明人:
FLYNN, BERNARD, LUKE,BAELL, JONATHAN, B,HARVEY, ANDREW, J,CHAPLIN, JASON, HUGH,PAUL, DHARAM,MOULD, JORGEN, ALVAR
申请号:
NZ57568607
公开号:
NZ575686A
申请日:
2007.10.04
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is a furochrome of formula (I) where the substituents are as disclosed in the description. Examples of compounds of the invention are: 7-Dimethylaminomethyl-9-[3-R-(3-(phenyl)butoxy)]-4-methyl-5H-furo[3,2-g]chromen-5-one 7-Dimethylaminomethyl-9-(3[4-fluorophenyl]propoxy)-4-methyl-5H-furo[3,2-g]chromen-5-one 4-Methyl-7-methylsulfanylmethyl-9-(3-phenylpropoxy)furo[3,2-g]chromen-5-one. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament for treating autoimmune or chronic inflammatory diseases, or the prevention of rejection of foreign organ transplants and/or related afflictions. Further disclosed is a method of intentionally modulating potassium ion channel activity of T-cells ex vivo by the application of a compound of formula (I)
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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