Rikki Peter Alexander,Gareth Neil Brace,Julien Alistair Brown,Mark Daniel Calmiano,Prafulkumar Tulshibhai Chovatia,Michael Deligny,Ellen Olivia Gallimore,Jag Paul Heer,Victoria Elizabeth Jackson,Boris
申请号：
US15101767
公开号：
US10087179B2
申请日:
2014.12.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A series of fused tricyclic imidazole derivatives, in particular dihydro-1H-cyclopenta[4,5]imidazo[1,2-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders； neurological and neurodegenerative disorders； pain and nociceptive disorders； cardiovascular disorders； metabolic disorders； ocular disorders； and oncological disorders.
