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New modulators of glutamatergic neurotransmission mediated by NMDA receptors and cortical dopaminergic
专利权人:
Integrative Research Laboratories Sweden AB
发明人:
SONESSON, Clas,KARLSSON, Jonas,SVENSSON, Peder
申请号:
ES12714704
公开号:
ES2566634T3
申请日:
2012.04.17
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A phenoxy-ethyl-amine derivative of Formula 1: ** Formula ** a stereoisomer or a mixture of its stereoisomers or one of its N-oxides or one of its totally or partially deuterated analogs or one of its pharmaceutically acceptable salts, where R1 represents CH3 or CF3; R2 is selected from the group consisting of C1-C4 alkyl, allyl, CH2CH2OCH3, C (CH3) 2CH2CH3, CH2-cyclopropyl, cyclobutyl, cyclopentyl, CH2CH2CH2F, CH2CH2CHF2, CH2CH2F, 3,3,3-trifluoropropyl and 4.4, 4- trifluorobutyl; and R3 is selected from the group consisting of H, CH3 and CH2CH3; or R2 and R3 together form CH2 (CH2) CH2 or CH2 (CH2) 3CH2; R4 represents F or Cl; and R 'and R "independently represent hydrogen or methyl.Un derivado de fenoxi-etil-amina de Fórmula 1:**Fórmula** un estereoisómero o una mezcla de sus estereoisómeros o uno de sus N-óxidos o uno de sus análogos total o parcialmente deuterado o una de sus sales farmacéuticamente aceptables, donde R1 representa CH3 o CF3; R2 se selecciona del grupo que consiste en alquilo de C1-C4, alilo, CH2CH2OCH3, C(CH3)2CH2CH3, CH2- ciclopropilo, ciclobutilo, ciclopentilo, CH2CH2CH2F, CH2CH2CHF2, CH2CH2F, 3,3,3-trifluoropropilo y 4,4,4- trifluorobutilo; y R3 se selecciona del grupo que consiste en H, CH3 y CH2CH3; o R2 y R3 forman juntos CH2(CH2)CH2 o CH2(CH2)3CH2; R4 representa F o Cl; y R' y R" representan independientemente hidrógeno o metilo.
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