#$%^&*AU2016208323B220180405.pdf#####Abstract: Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and nonneoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.1/25 VEGF Regulation 100- Compound #10 90- Compound 1205 80- o Compound 1330 706050S403020100--- -------------------------------------10 1111111 1 1 11111111 11111111 10-5 10-4 10-3 10-2 10-1 100 Log [uM] Fig. 1
