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Cationic lipid
专利权人:
EISAI R&;D MANAGEMENT CO.; LTD.
发明人:
Yuta Suzuki,Yoshinori Takahashi
申请号:
US16307202
公开号:
US10501416B2
申请日:
2017.06.22
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present invention provides a cationic lipid which is able to be used for nucleic acid delivery to the cytoplasm. A cationic lipid according to the present invention is, for example, a compound represented by formula (1a) or a pharmaceutically acceptable salt thereof. (In formula (1a), each of L1 and L2 independently represent an alkylene group having 3-10 carbon atoms; each of R1 and R2 independently represent an alkyl group having 4-22 carbon atoms or an alkenyl group having 4-22 carbon atoms; X1 represents a single bond or —;CO—;O—;; and ring P represents one of formulae (P-1) to (P-5).) (In formulae (P-1) to (P-5), R3 represents an alkyl group having 1-3 carbon atoms.)
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