The present invention relates to the use of antagonists of oxytocin,antagonists of oxytocin and vasopressin or antagonists of vasopressin, ortheir pharmaceutically accepted salts, or their combinations with other drugsfor the manufacture of a medicament which main profile of action is inhibitionof oxytocin and/or vasopressin receptors in non-pregnant uterus of mammals,that results in improvement of uterine receptivity in embryo transfer. Itfurther relates to the application of these substances for the manufacture ofa medicament for regulating the uterine contractile activity in cases ofartificial insemination.