The present invention relates to a device for skin conductance measurement in a frequency range up to at least 50 Hz. The proposed device comprises two measurement terminals (23, 24) for applying a constant DC voltage to a skin area, a first measurement path (27) coupled between a first of said measurement terminals (23) and a first output terminal (25), a second measurement path (28) coupled between the second measurement terminals (24) and a second output terminal (26), two output terminals (25, 26) each providing a respective measurement voltage, the difference of which being related to the skin conductance of said skin area. This provide for cancelation of noise when measuring the difference at the output terminals.