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Fused cyclooctin compounds and their use in metal-free click reactions
专利权人:
SYNAFFIX B.V.
发明人:
VAN DELFT, FLORIS,RUTJES, FLORIS,DOMMERHOLT, FREDERIK
申请号:
ES11720197
公开号:
ES2527536T3
申请日:
2011.04.26
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compound of Formula (IIa): ** Formula ** where: p is 0 or 1; R3 is selected from the group consisting of [(L) p-Q], hydrogen, halogen, C1-C24 alkyl groups, C6-C24 (hetero) aryl groups, C7-C24 alkyl (hetero) aryl groups and (hetero) arylalkyl groups C7-C24, the alkyl groups being optionally interrupted by one of several heteroatoms selected from the group consisting of O, N and S, where the alkyl groups, (hetero) aryl groups, alkyl (hetero) aryl groups and (hetero) arylalkyl groups are optionally independently substituted with one or more substituents independently selected from the group consisting of C1-C12 alkyl groups, C2-C12 alkenyl groups, C2-C12 alkynyl groups, C3-C12 cycloalkyl groups, C1-C12 alkoxy groups, C2-C12 alkyloxy groups, C2-C12 alkynyloxy groups, C3-C12 cycloalkyloxy groups, halogens, amino groups, oxo groups and silyl groups, where alkyl groups, alkenyl groups, alkynyl groups, cycloalkyl groups, alkoxy groups, alkenyloxy groups, alkynyloxy groups and Cycloalkyloxy groups are optionally substituted, alkyl groups, alkoxy groups, cycloalkyl groups and cycloalkoxy groups being optionally interrupted by one of several heteroatoms selected from the group consisting of O, N and S, where silyl groups are represented by the formula ( R4) 3Si-, where R4 is independently selected from the group consisting of C1-C12 alkyl groups, C2-C12 alkenyl groups, C2-C12 alkynyl groups, C3-C12 cycloalkyl groups, C1-C12 alkoxy groups, C2-C12 alkyloxy groups, C2-C12 alkynyloxy groups and C3-C12 cycloalkyloxy groups, where alkyl groups, alkenyl groups, alkynyl groups, cycloalkyl groups, alkoxy groups, alkenyloxy groups, alkynyloxy groups and cycloalkyloxy groups are optionally substituted, alkyl groups, alkoxy groups, cycloalkyl groups and cycloalkoxy groups being optionally interrupted by one of several heteroatoms selected from the group consisting of O , N and S; L is a linking group selected from C1-C24 alkylene groups, C2-C24 alkenylene groups, C2-C24 alkynylene groups,
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