The present disclosure relates to a medical device and methods of using thesame. In embodiments, the medical device may be a buttress formed ofnucleophilicbuttress components and electrophilic buttress components which react to bothformthe buttress and provide the buttress with self-sealing capabilities after astaple orsome other fixation device is placed therethrough, thereby enhancing itshemostaticproperties. In other embodiments, the medical device is a hernia patch formedof afibrous substrate, nucleophilic precursor components and electrophilicprecursorcomponents.