The invention discloses a kind of pharmaceutical composition and its application.Pharmaceutical composition disclosed by the invention includes one or more and androgen receptor pathway modulators in the Benzoheterocyclic compounds shown in logical formula (I), its pharmaceutically acceptable salt, solvate, crystal formation, eutectic, stereoisomer, isotopic compound, metabolite and prodrug.The pharmaceutical composition of the present invention can more effectively suppress the growth of prostate gland cancer cell.
