David E. Clements;Kae Myriam Pusic;George N.S. Hui
发明人:
David E. Clements,Kae Myriam Pusic,George N.S. Hui
申请号：
US13510923
公开号：
US20120231029A1
申请日:
2010.11.18
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Recombinant subunit proteins derived from the MSP-1 C-terminal region of the parasite Plasmodium falciparum are described that have enhanced immunogenic properties. Selected regions of p33 have been combined with p19 to enhance the immunogenic potential of the p19 core region. As the constructs represent discontinuous segments fused to create unique proteins, the recombinant proteins expressed are not found in nature. The enhanced immunogenic potential of the disclosed recombinant proteins provided for strong, consistent and specific antibody responses. The disclosed recombinant subunit proteins are vaccine candidates for protection against infection with malaria.
