A method for suturing a patent foramen ovale (PFO) includes providing a suturing device, advancing the suturing device through the inferior vena cava, right atrium, and PFO such that a first foot of the device is positioned in the left atrium, deploying the first foot to a deployed position, orienting the suturing device such that a distal portion of tissue of the PFO is received in a pre-formed curve portion of a foot housing of the device, advancing the first needle through tissue and further into a first needle receptacle disposed on the first foot, and advancing at least one end of the length of suture through the tissue to suture the PFO.
