Moussa B. H. Youdim;Rivka Warshawsky;Hailin Zheng;Matitiyahu Fridkin
发明人:
Moussa B. H. Youdim,Matitiyahu Fridkin,Hailin Zheng,Abraham Warshawsky
申请号：
US13296061
公开号：
US08685955B2
申请日:
2011.11.14
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Novel iron chelators exhibiting neuroprotective and good transport properties are useful in iron chelation therapy for treatment of a disease, disorder or condition associated with iron overload and oxidative stress, e.g., a neurodegenerative or cerebrovascular disease or disorder, a neoplastic disease, hemochromatosis, thalassemia, a cardiovascular disease, diabetes, an inflammatory disorder, anthracycline cardiotoxicity, a viral infection, a protozoal infection, a yeast infection, retarding aging, and prevention and/or treatment of skin aging and skin protection against sunlight and/or UV light. The iron chelator function is provided by a 8-hydroxyquinoline, a hydroxypyridinone or a hydroxamate moiety. The neuroprotective function is imparted to the compound, e.g., by a neuroprotective peptide. A combined antiapoptotic and neuroprotective function is provided by a propargyl group.
