TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.;YEDA RESEARCH AND DEVELOPMENT CO. LTD.
发明人:
WARSHAWSKY, ABRAHAM,YOUDIM, MOUSSA B. H.,FRIDKIN, MATITIYAHU,ZHENG, HAILIN
申请号：
CA2505476
公开号：
CA2505476C
申请日:
2003.11.07
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Novel iron chelators exhibiting neuroprotective and good transport properties are useful in iron chelation therapy for treatment of a disease, disorder or condition associated with iron overload and oxidative stress, eg. a neurodegenerative or cerebrovascular disease or disorder, a neoplastic disease, hemochromatosis, thalassemia, a cardiovascular disease, diabetes, a inflammatory disorder, anthracycline cardiotoxicity, a viral infection, a protozoal infection, a yeast infection, retarding ageing, and prevention and/or treatment of skin ageing and skin protection against sunlight and/or UV light. The iron chelator function is provided by a 8-hydroxyquinoline, a hydroxypyridinone or a hydroxamate moiety, the neuroprotective function is imparted to the compound e.g. by a neuroprotective peptide, and a combined antiapoptotic and neuroprotective function by a propargyl group.
