Disclosed herein are anti-RGMa antibodies and methods of using these antibodies to treat spinal cord injury, including promoting axonal regeneration, functional recovery, or both and to treat pain, including neuropathic pain arising from spinal cord injury.本發明揭示抗RGMa抗體及使用此等抗體治療脊髓損傷(包括促進軸突再生、功能恢復或兩者)以及治療疼痛(包括由脊髓損傷引起之神經痛)之方法。