Manuel Jesús Alcázar-Vaca;P. Jeffrey Conn;Susana Conde-Ceide;Han Min Tong;Carrie K. Jones;Shaun R. Stauffer;José Manuel Bartolomé-Nebreda;José Ignacio Andrés-G;Gregor James MacDonald;Craig W. Lindsley
发明人:
P. Jeffrey Conn,Craig W. Lindsley,Shaun R. Stauffer,José Manuel Bartolomé-Nebreda,Susana Conde-Ceide,Gregor James MacDonald,Han Min Tong,Carrie K. Jones,Manuel Jesús Alcázar-Vaca,José Ignacio Andrés-G
申请号：
US13329025
公开号：
US08592422B2
申请日:
2011.12.16
申请国别(地区):
US
年份:
2013
代理人:
摘要：
In one aspect, the invention relates to bicyclic triazole and pyrazole lactams, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5)； synthetic methods for making the compounds； pharmaceutical compositions comprising the compounds； and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
