Simon Plyte;Marco Ballarini;Giacomo Carenzi;Manuela Villa;Mario Varasi;Saverio Minucci;Gilles Pain;Daniele Fancelli;Anna Cappa
发明人:
Daniele Fancelli,Mario Varasi,Simon Plyte,Marco Ballarini,Anna Cappa,Giacomo Carenzi,Saverio Minucci,Gilles Pain,Manuela Villa
申请号：
US13874081
公开号：
US08669261B2
申请日:
2013.04.30
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Acrylamido derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of the mitochondrial permeability transition pore (MPTP), such as the diseases characterized by ischemia/reperfusion, oxidative or degenerative tissue damage, are herein described. These compounds belong to the structural formula (I) wherein R, R′, R″, W and a are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to pharmaceutical compositions comprising them.
