The present invention relates to the technical field of biomedicine, in particular to a pharmaceutical product, comprising a compound (a), or a pharmaceutically acceptable salt, an ester or a solvate thereof, or a stereisomer thereof, and at least one cephalosporin antibiotic or a derivative thereof, wherein the compound (a) has the structure as shown in formula (I). The present invention also relates to a method for preventing and/or treating infectious diseases induced by bacteria in a subject, comprising administering a prophylactically or therapeutically effective amount of compound (a), or a pharmaceutically acceptable salt, an ester or a solvate thereof, or a stereisomer thereof, and at least one cephalosporin antibiotic or a derivative thereof to the subject and preferably, the bacteria have a drug resistance induced by [beta]-lactamase.本發明涉及醫藥技術領域,具體一種藥物產品,其包含化合物(a)、或其藥學上可接受的鹽、酯或溶劑化合物、或其立體異構體,以及至少一種頭孢類抗生素或其衍生物,其中,該化合物(a)具有式(I)所示的結構。 本發明還涉及一種預防和/或治療受試者中由細菌引起的感染性疾病的方法,包括給受試者施用預防和/或治療有效量的化合物(a)、或其藥學上可接受的鹽、酯、溶劑化合物或其立體異構體,以及至少一種頭孢類抗生素或其衍生物;較佳地,該細菌具有由β-內醯胺酶引起的耐藥性。
