The present invention provides a method for estimating central aortic pulse pressure by cuff pressure pulse wave oscillation signals, comprising: (I) providing an equation for estimating central aortic pulse pressure (II) measuring pressure pulse wave oscillation signals in a cuff, which comprise a brachial systolic blood pressure, a diastolic blood pressure and a waveform of the pressure pulse wave oscillation signals in the cuff (III) averaging the waveform of the pressure pulse wave oscillation signals and calibrating the averaged waveform by the systolic blood pressure and diastolic blood pressure (IV) analyzing the calibrated pressure pulse wave oscillation signal waveform to obtain a plurality predicting variables and (V) obtaining an estimate of central aortic pulse pressure by values of predicting variables in step (IV) and the equation in step (I). The present invention further provides a device for estimating central aortic pulse pressure by the method of the present invention.
