Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides such as carrageenans including lambda carrageenan as well as water soluble metal salts and specified antiretroviral agents comprising NNRTIs and NRTIs. Also disclosed are methods for making and using the compositions. Also disclosed are intravaginal rings for delivering water soluble compounds and preferably high molecular weight water soluble polymers at essentially a zero order rate. The rings include an outer layer of non water swellable elastomer and preferably high molecular weight water soluble polymer and an inner layer of the water soluble polymer which is imbedded in the outer layer and an aperture through the outer layer for release thereof only through that aperture.
