Janet A. Halliday,Jukka Tuominen,Mark Livingstone,Frank Koppenhagen,Lilias Currie,Sarah Stewart
申请号：
US13571596
公开号：
US08628798B2
申请日:
2012.08.10
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1-2.5. The polyurethane is water-swellable in the range 300 to 1700% and soluble in certain organic solvents such as dichloromethane. It can be loaded with pharmaceutically active agents, particularly of high molecular weight, to produce controlled release compositions, such as pessaries etc.
