Leek, Michael David,Hannigan, Adele,Patakas, Agapitos,Paruzina, Daria
申请号:
AU2016250211
公开号:
AU2016250211A1
申请日:
2016.04.14
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
The present invention provides composition and methods for the treatment of cancer or infectious diseases in a human. The invention includes the generation and administration of gamma delta Τ cells that express chimeric antigen receptors (CARs) comprising an antigen binding domain, a hinge domain, a transmembrane domain, a costimulatory signalling domain with the inclusion or not of a CD3 zeta signalling domain. Expression of CAR sequence omitting the CD3 zeta signalling domain in gamma delta T cells, provides for a CAR-T therapy in vivo, which will effect cytolysis only on target cells providing ligands for activation of the gamma delta T cell receptor (TCR).