TAMAI, Katsuto,YAMAZAKI, Takehiko,KANEZAKI, Tsutomu,SAKURAI, Shigeru,NOGUCHI, Yukiko,ENDO, Mayumi,HAMABUCHI, Natsumi,NAITO, Kana
申请号：
DK12777041
公开号：
DK2703487T3
申请日:
2012.04.03
申请国别(地区):
DK
年份:
2018
代理人:
摘要：
(Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFR±-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body. (Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFR±-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFR±-positive cells.
