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Peptides and their use to induce tissue regeneration
专利权人:
株式会社ジェノミックス;国立大学法人大阪大学
发明人:
玉井 克人,山崎 尊彦,金崎 努,櫻井 滋,野口 由紀子,遠藤 真弓,濱渕 夏美,内藤 佳奈
申请号:
JP2013511983
公开号:
JP6069191B2
申请日:
2012.04.03
申请国别(地区):
JP
年份:
2017
代理人:
摘要:
(Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFR±-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body. (Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFR±-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFR±-positive cells.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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