Provided are a therapeutic agent and a prophylactic agent for keratoconjunctive disorder, each agent comprising sacran. A therapeutic agent or a prophylactic agent for keratoconjunctive disorder, each agent comprising sacran.本發明之課題在於提供一種含有硫酸多醣(sacran)之角結膜障礙之治療劑及預防劑。本發明係關於一種含有硫酸多醣之角結膜障礙之治療劑或預防劑。