Lucas James THOMPSON,Valerie ODEGARD,Blythe SATHER,Archana BRAHMANDAM
申请号：
US15773540
公开号：
US20180319862A1
申请日:
2016.11.04
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided are chimeric receptors for engineering cells for adoptive therapy, including T cells, and the genetically engineered cells. In some aspects, also provided are methods and compositions for engineering and producing the cells, compositions containing the cells, and method for their administration to subjects. In some embodiments, the cells, such as T cells, contain genetically engineered antigen receptors that specifically bind to antigens, such as a chimeric antigen receptor (CAR), and which contain an intracellular signaling domain capable of inducing TRAF6-mediated signaling. In some embodiments, features of the cells and methods provide for increased or improved activity, efficacy and/or persistence.
