Gottschalk, Stephen M. G,Shaffer, Donald R.,Spencer, David M.
申请号:
AU2011319727
公开号:
AU2011319727B2
申请日:
2011.10.27
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
The present invention concerns methods and compositions related to T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies. In aspects of the invention, T cells that are CD70-specific are employed. In particular aspects, there are T cells expressing a novel molecule that comprises the full-length CD70 receptor (CD27) fused to the zeta signaling domain of the T-cell receptor complex. Such T cells recognized CD70- positive tumor cells and have cytolytic activity against CD70-positive cancer cells.