DORSCH, DIETER,JONCZYK, ALFRED,HOELZEMANN, GUENTER,AMENDT, CHRISTIANE,ZENKE, FRANK
申请号：
ES12704233
公开号：
ES2542647T3
申请日:
2012.02.13
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Compound of formula (I) ** Formula ** where: X indicates absent, NR4 or CR5R6； R1 indicates a monocyclic aryl having 3, 4, 5, 6, 7 or 8 C atoms or a monocyclic heteroaryl having 1, 2, 3, 4, 5, 6, 7 or 8 atoms of C and 1, 2, 3, 4 or 5 atoms of N, O and / or S, each of which may be independently substituted from each other by at least 10 a substituent selected from the group consisting of Y, Hal, CN, CF3 and OY； R2 indicates H, A, -OY, -NH2 or -NAA； R3 indicates H, A, -OY or -NYY； R4, R5, R6 independently indicate each other absent, H, A； R7 indicates Hal, A, - (CYY) n-OY, - (CYY) n-NYY, (CYY) n-Het2, (CYY) nO-Het215, SY, NO2, CN, COOY, - CO-NYY, - NY-COA, -NY-SO2A, -SO2-NYY, S (O) mA, -CO-Het2, -O (CYY) n-NYY, -O (CYY) n-Het2, - NH-COOA, -NH -CO-NYY, -NH-COO- (CYY) n-NYY, -NH-COO- (CYY) n-Het2, -NH-CO-NH- (CYY) n- NYY, -NH-CO-NH ( CYY) n-Het2, -OCO-NH- (CYY) n-NYY, -OCO-NH- (CYY) n-Het2, CHO, COA,>； = S,>； = NY and>； = O； Y indicates H or A； A indicates a branched or unbranched alkyl having 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 C atoms, in which 1, 2, 3, 4, 5, 6 or 7 atoms of H may be independently substituted for each other by Hal and / or in which one or two CH2 groups may be independently substituted for each other by O, S, SO, SO2, a group -CY>； = CY- and / or a group - C-, or indicates cyclic alkyl with 3, 4, 5, 6 or 7 C atoms； Het indicates a saturated, unsaturated mono, bi or tricyclic heterocycle having 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 atoms of C and 1, 2, 3, 4 or 5 atoms of N, O and / or S, which may be independently substituted from each other by at least one R7 substituent； Het2 indicates a saturated, unsaturated mono, bi or tricyclic heterocycle having 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 atoms of C and 1, 2, 3, 4 or 5 atoms of N, O and / or S, which may be independently substituted from each other by at least one substituent selected from the group consisting of Hal, A, - (CYY) n -OY, - (CYY
