MODULE REPLICATION FITNESS USING A LESS ACTION SYNONYMOUS CODONES

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专利权人:

The Government of The United States of America as represented by The Secretary of The Department of Health and Human Services

发明人:

KEW, Olen, M,BURNS, Cara, C,SHAW, Jing,CAMPAGNOLI, Raymond,QUAY, Jacqueline

申请号：

DK17205518

公开号：

DK3312272T3

申请日:

2005.10.07

申请国别(地区):

DK

年份:

2019

代理人:

摘要：

Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.

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