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Treatment or prevention of infection
专利权人:
ОРАЛ ХЭЛС АУСТРАЛИА ПТИ ЛТД (AU)
发明人:
РЕЙНОЛДС Эрик Чарльз (AU)
申请号:
RU2012136724/15
公开号:
RU2012136724A
申请日:
2011.02.25
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of treating a disease or condition associated with the presence of a pathogen in the oral tissue of a subject, comprising administering an anti-inflammatory agent and / or an antimicrobial agent, and administering an immunogen that elicits an immune response against P. gingivalis. 2. The method according to claim 1, comprising administering an anti-inflammatory agent in an amount effective to reduce inflammation of the oral tissue of said subject. The method according to claim 1, comprising administering an antimicrobial agent in an amount effective to remove microorganisms or fragments thereof from the oral tissue of said subject. The method according to claim 1, wherein said antimicrobial agent is an agent that inhibits fumarate reductase. The method according to claim 1, wherein said antimicrobial agent is selected from the group consisting of oxantel, morantel and thiabendazole. The method of claim 1, wherein said immunogen is a chimeric peptide or P. gingivalis fusion protein. The method of claim 6, wherein said chimeric peptide or P. gingivalis fusion protein is selected from the group consisting of KAS1-KsA1 and KAS2-KLA1.8. The method of claim 1, wherein said agent and / or immunogen is administered systemically. The method of claim 1, wherein said agent and / or immunogen is administered directly to the tissue of the oral cavity. The method of claim 1, wherein said agent and immunogen are administered simultaneously. The method of claim 1, wherein said immunogen is administered after administration of said agent. The method of claim 1, wherein said immunogen is administered one to two weeks after administration of said agent. The method according to claim 1, agrees1. Способ лечения заболевания или состояния, ассоциированного с присутствием патогена в ткани ротовой полости у субъекта, включающийвведение противовоспалительного агента и/или противомикробного агента, ивведение иммуногена, который вызывает иммунный ответ против Р. gingivalis.2. Спосо
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